The current proposal has the general aim of evaluating the environmental quality of the water and sediment of the Potiritá and Capim rivers in the Paragominas region, under the influence of the Norsk Hydro Mining company. An integrated approach using physical, chemical and biological tools through examining metal concentrations, histopathological and biochemical biomarkers; and population genetics and ecology of bivalves. This information will allow an understanding of anthropogenic disturbances in the aquatic environment and their effects on the biota, serving as a subsidy for the area’s water resources monitoring program.