[Conteúdo apenas disponível em inglês]

University of Aveiro, 14 Mar 2018

Concluding remarks

• Functional link between protein aggregation, inflammation and autophagy in human pDCs allows the development of novel therapies against inflammatory conditions.
• Modulation of immune cells and its interactions with other cell types allows to take advantage of immune responses for novel regenerative therapies.
• Functional intersection between autophagy and TLR signaling in human pDCs function enables development of novel therapies against infections or to treat autoimmune diseases.
• CAL-1 cells are a good cell model for pDC activation with immune complexes.
• The interaction between vMIA and MFF at the peroxisomal membrane is essential for vMIA’s-dependent inhibition of the antiviral immune response.
• Flow cytometry is a complete tool to analyze different parameters at single cell level, are used as biomarkers of disease progression.
• The pro- or anti-inflammatory action of modified amino-phospholipids appears to be related with its molecular species and type of modification.
• Targeting lipid-related pathways is a promising strategy to modulate macrophages phenotype towards enhanced pro-resolving activity.
• Metabolism targeting should modulate macrophage polarization.