NM-OREO: uso de uma abordagem NM-(bio)molecula cOrona para compReender os mEcanismos de tOxicidade – um estudo de biologia de sistemas de impacto ambiental

Coordenador

Mónica Amorim

Programa

Projetos de Investigação Científica e Desenvolvimento Tecnológico - 2014 (PTDC/AAG-MAA/4084/2014)

Datas

11/07/2016 - 31/03/2020

Financiamento para o CESAM

199980 €

Financiamento Total

199980 €

Instituições Participantes

  • Universidade de Aarhus
  • Universidade de Rovira e Virgil
  • Colorado School of Mines

[conteúdo apenas disponível em inglês]

When manufactured nanomaterials (NMs) encounter any environment, they are immediately covered by molecules that form a corona, i.e. a layer around the NM. To date, NM research and development of standardization protocols have mostly focused on pristine and in-use NM. The in situ corona formation on NMs can include binding of abiotic inorganic and organic material. As a result, organisms do not directly interact with bare NMs (pristine), but rather with corona-coated NMs. Nevertheless, there is very little knowledge in this area, especially for environmental species. Thus, developing an understanding of the interactions between the NM, the corona-forming molecules, and the biological impact may very well be critical in evaluating risks associated to NMs. This could subsequently determine the future acceptance of NMs in commercial products.
NM-OREO’s mission is to advance knowledge by providing useful models that support a realistic assessment of environmental risks posed by NMs. In a broader context, this will support the sustainable exploitation of nanotechnology in Europe, the US and worldwide. To address this issue, a highly interdisciplinary team has joined forces to measure, understand and model the impact of coronas on NM interacting with both environmental and biological matrices.

membros do CESAM no projeto

Mónica João de Barros Amorim

Investigadora Principal com agregação

Susana Isabel Lopes Gomes

Investigadora Auxiliar

Vera Lúcia de Almeida Maria

Investigadora Doutorada